Long-Term Stability of Benefits of Cognitive Behavioral Therapy for Obsessive Compulsive Disorder Depends on Symptom Remission During Treatment

Authors

  • Björn Elsner
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Frieder Wolfsberger
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Jessica Srp
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Antonia Windsheimer
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Laura Becker
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Tanja Jacobi
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Norbert Kathmann
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany
  • Benedikt Reuter
    Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany

Abstract

Background: Cognitive behavioral therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) and may afford stable long-term improvements. It is not clear, however, how stability or symptom recurrence can be predicted at the time of termination of CBT.


Method: In a 1-year follow-up intention-to-treat study with 120 OCD patients receiving individual CBT at a university outpatient unit, we investigated the predictive value of international consensus criteria for response only (Y-BOCS score reduction by at least 35%) and remission status (Y-BOCS score ≤ 12). Secondly, we applied receiver-operating characteristic (ROC) curves in order to find an optimal cut-off score to classify for deterioration and for sustained gains.


Results: Response only at post-treatment increased the likelihood of deterioration at follow-up compared to remission at an odds ratio of 8.8. Moreover, ROC curves indicated that a post-treatment score of ≥ 13 differentiated optimally between patients with and without symptom deterioration at follow-up assessment. The optimal cut-off score to classify for any sustained gains (response, remission, or both) at follow-up relative to baseline was 12. Importantly, previous findings of generally high long-term symptom stability after treatment in OCD could be replicated.


Conclusion: The findings highlight the clinical importance of reaching remission during CBT, and suggest that a recently published expert consensus for defining remission has high utility.